Good Sam Cast, Recurring Cast & Guest Stars 2025
Find out the main cast, recurring cast and guest stars for the 2025 season.
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Main Cast 2025
Sophia Bush as Dr. Sam Griffith
Jason Isaacs as Dr. Rob “Griff” Griffith
Skye P. Marshall as Dr. Lex Trulie
Michael Stahl-David as Dr. Caleb Tucker
Davi Santos as Dr. Joey Costa
Omar Maskati as Dr. Isan M. Shah
Wendy Crewson as Vivian Katz
Edwin Hodge as Malcolm A. Kingsley
Guest Stars 2025
Marium Carvell as Nurse Donna Williams
Sendhil Ramamurthy as Asher Pyne
Evan Parke as Byron Kingsley
Victoria Rowell as Tina Kingsley
Yanna McIntosh as Dr. Rhonda Glass
Travis Van Winkle as Dr. Eric Kace
Douglas E. Hughes as Bernie
Gerardo Celasco as Dr. Nick Vega
Brian Paul as Dr. Alex Anders
Indy Saluja as E.R. Doctor
Pearl Sun as Crash Nurse
Tonight’s Cast & Guest Stars
Scroll down for the cast and guest stars for the latest episode.